MovDisordV3, Main, Exploration, bibRecord, 004C04

Worsening of motor performance in patients with Parkinson's disease following transdermal nicotine administration

Identifieur interne : 004C04 ( Main/Exploration ); précédent : 004C03; suivant : 004C05

Worsening of motor performance in patients with Parkinson's disease following transdermal nicotine administration

Auteurs : Georg Ebersbach [Autriche] ; Michael Stöck [Autriche] ; Jörg Müller [Autriche] ; Gregor Wenning [Autriche] ; Jörg Wissel [Autriche] ; Werner Poewe [Autriche]

Source :

Movement Disorders [ 0885-3185 ] ; 1999-11.

RBID : ISTEX:38FB2ADD91058F41ABAF5A1581A5916EFC2D82A7

Descripteurs français

Pascal (Inist)
- Homme, Nicotine, Parkinson maladie, Patch, Toxicité, Trouble moteur, Voie administration.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Administration, Cutaneous, Adult, Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Corpus Striatum (drug effects), Corpus Striatum (physiology), Cross-Over Studies, Dopamine (physiology), Double-Blind Method, Drug Therapy, Combination, Female, Human, Humans, Male, Middle Aged, Motor Skills (drug effects), Motor Skills (physiology), Motor performance, Motor system disorder, Neural Inhibition (drug effects), Neural Inhibition (physiology), Nicotine, Nicotine (administration & dosage), Nicotine (adverse effects), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Patch, Route of administration, Substantia Nigra (drug effects), Substantia Nigra (physiopathology), Toxicity.
MESH :
- chemical , administration & dosage : Antiparkinson Agents, Nicotine.
- chemical , adverse effects : Antiparkinson Agents, Nicotine.
- drug effects : Corpus Striatum, Motor Skills, Neural Inhibition, Substantia Nigra.
- drug therapy : Parkinson Disease.
- physiology : Corpus Striatum, Dopamine, Motor Skills, Neural Inhibition.
- physiopathology : Parkinson Disease, Substantia Nigra.
- Administration, Cutaneous, Adult, Aged, Cross-Over Studies, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged.

Abstract

Nicotine has been reported to have positive effects on motor performance in patients with Parkinson's disease. In this study, motor performance was evaluated in 16 patients with idiopathic Parkinson's disease during a practical off‐period using the motor part of the Unified Parkinson's Disease Rating Scale after 12 hours' exposure to a transdermal patch containing 35 mg nicotine or placebo. The study was performed using a double‐blind crossover design. In contrast to previous reports, nicotine exposure was followed by a worsening of symptoms compared with placebo. A negative response to subthreshold dopaminergic stimulation, resulting from an inhibitory effect of low striatal dopamine concentrations acting on a subset of dopamine receptors, might possibly account for this finding.

Url:

https://api.istex.fr/document/38FB2ADD91058F41ABAF5A1581A5916EFC2D82A7/fulltext/pdf

DOI: 10.1002/1531-8257(199911)14:6<1011::AID-MDS1016>3.0.CO;2-F

Affiliations:

Le document en format XML

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<author><name sortKey="Muller, Jorg" sort="Muller, Jorg" uniqKey="Muller J" first="Jörg" last="Müller">Jörg Müller</name>
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<term>Corpus Striatum (drug effects)</term>
<term>Corpus Striatum (physiology)</term>
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<term>Neural Inhibition (physiology)</term>
<term>Nicotine</term>
<term>Nicotine (administration & dosage)</term>
<term>Nicotine (adverse effects)</term>
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<term>Parkinson Disease (physiopathology)</term>
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<front><div type="abstract" xml:lang="en">Nicotine has been reported to have positive effects on motor performance in patients with Parkinson's disease. In this study, motor performance was evaluated in 16 patients with idiopathic Parkinson's disease during a practical off‐period using the motor part of the Unified Parkinson's Disease Rating Scale after 12 hours' exposure to a transdermal patch containing 35 mg nicotine or placebo. The study was performed using a double‐blind crossover design. In contrast to previous reports, nicotine exposure was followed by a worsening of symptoms compared with placebo. A negative response to subthreshold dopaminergic stimulation, resulting from an inhibitory effect of low striatal dopamine concentrations acting on a subset of dopamine receptors, might possibly account for this finding.</div>
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Movement Disorders (revue)

Worsening of motor performance in patients with Parkinson's disease following transdermal nicotine administration

Worsening of motor performance in patients with Parkinson's disease following transdermal nicotine administration

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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